File - Type 1 Diabetes Is Caused By A Mutated Gene. Document

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. This gene is located on the X chromosome, which is one of the two sex Managing Type 1 Diabetes. T1D is caused by autoimmune-mediated beta cell destruction leading to insulin deficiency.

 
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Up to 5% of all diabetes cases may be due to MODY. Donath and his team performed additional studies with animal models of type 1 diabetes. About 80 percent of cases are caused by mutations in the COL4A5 gene and are inherited in an X-linked pattern. It is caused by a change in a gene that affects insulin production. MODY is often referred to as "monogenic diabetes"[3][4] to distinguish it from the more common types of diabetes (especially type 1 and type 2), which involve more complex combinations of causes The diagnosis of MODY is confirmed by specific gene testing available through commercial laboratories. The hormone GIP is produced by the intestine after eating and is an important regulator of insulin secretion.



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